About Me

My name is Matt Myers, and I amm a senior computational biologist with a focus on cancer genomics. I work in the Shah lab in the Halvorsen Center for Computational Oncology at Memorial Sloan Kettering Cancer Center, where I focus on computational methods, analysis, and software to study tumor evolution.

In 2022 I completed my PhD in Ben Raphael's group in the Computer Science Department at Princeton University, where I developed algorithms to infer genetically distinct tumor subpopulations (clones) from DNA sequencing data (see below).

My other interests include birdwatching, wildlife photography, veganism, music, and cooking.

Email: m [at] myersmatthew [dot] com

Selected Publications:

Myers, M. A., Satas, G., Shah, S. P., & McPherson, A. (2026). scPlOver: Inferring DNA content from amplification-free single-cell WGS using fragment overlaps. bioRxiv, 2026.05.06.722337.
Satas, G., Myers, M. A., & Shah, S. P. (2026). Statistical inconsistency of error-correction objectives for perfect phylogenies. Workshop on Algorithms in Bioinformatics (WABI 2026), LIPIcs, 23. https://drops.dagstuhl.de/entities/document/10.4230/LIPIcs.WABI.2026.23
Lee, J. J.-K., Salehi, S., Myers, M. A., …, & Shah, S. P. (2026). Evolution of oncogene amplification across 86,000 cancer cell genomes. bioRxiv, 2026.02.12.705658.
McPherson, A., Vázquez-García, I., Myers, M. A., …, & Shah, S. P. (2025). Ongoing genome doubling shapes evolvability and immunity in ovarian cancer. Nature, 644(8078), 1078–1087.
Myers, M. A., Arnold, B. J., Bansal, V., Balaban, M., Mullen, K. M., Zaccaria, S., & Raphael, B. J. (2024). HATCHet2: Clone- and haplotype-specific copy number inference from bulk tumor sequencing data. Genome Biology, 25, 130.
Myers, M. A., Zaccaria, S., & Raphael, B. J. (2020). SBMClone: Identifying tumor clones in sparse single-cell mutation data. Bioinformatics, 36(Supplement_1), i186–i193.
Li, B., Brady, S. W., Ma, X., Shen, S., Zhang, Y., Li, Y., …, Myers, M. A., …, & Zhang, J. (2020). Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia. Blood, 135(1), 41–55.
Myers, M. A., Satas, G., & Raphael, B. J. (2019). CALDER: Inferring tumor evolution from longitudinal samples. Cell Systems, 8(6), 514–522.

CV (updated Nov. 2026):

CV_nov2026.pdf